脂多糖气管内滴注对大鼠膈肌mafbx mrna影响.docxVIP

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脂多糖气管内滴注对大鼠膈肌mafbx mrna影响.docx

脂多糖气管内滴注对大鼠膈肌mafbx mrna影响.docx

?英文论著摘要?TheeffectofLipopolysaccharideontheMAFbxmRNAofdiaphragmaticinratsobjectiveToinvestigatetheexpressionofdiaphragmaticMuscleAtrophyFactorMAFbxmRNA(MuscleAtrophyF—Boxprotein)inrats丽tllAcuteLungInjuryinducedbylipopolysaccharide(LPS).MethodsEighteenSpragueDawley(SD)ratswerealocatedrandomlyintothreegroups:acontrolgroup(n=6),aLPS4hgroup(n=6)andaLPS24hgroup(n=6).FreshlungandDiaphragmaticsamplesweretakenat4hand24hafter1001上g/kgLPSinstilledintothetracheaoftherats.Normalsaline(0.5ml/kg)wasinstilledinthecontrolgroup.pathologicalchangeswereobservedOllthelungtissue,andMAFbxmRNAofdiaphragmaticmuscletis

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