以Holder指数情势和多重仿射性分析来区分完全基因中的编码和非编码序列.pdfVIP

Æ℄ Æ DNA DNA Æ H¨older γ (−2) γ (6) Æh H¨older Æ DNA (γ (−2)γ (6)h) Fisher 51 p , p , q c nc c qnc 66.53%, 83.34%, 71.63% 83.54% Æ/ ¨ Holder I ABSTRACT Accurate prediction of genes in genomes has always been a challenging task for bioinformaticians and computational biologists. Therefore, the discovery of existence of distinct scaling relations in coding and non-coding sequences has led to new perspectives in the understanding of the DNA sequences. This has motivated us to find new ways for characterization and classification of coding and non-coding sequences. In this thesis, we first introduce a number sequence representation of DNA sequences proposed by our group.Multiaffinity analysis and H¨older formalism are then performed on the representation of the obtained number sequence. Three suited exponents are selected to form a parameter space. The two exponents γ (−2), γ(6) are from Multiaffinity analysis, the exponent h is from H¨older for- malism. Each coding or non-coding sequence may be represented by a point in the three-dimensional parameter space. We can see the points corresponding to coding and non-coding sequences in the complete genome of many prokaryotes be divided to different regions roughly. If the point (γ (−2)γ (6)h) for a DNA se