冠脉内替罗非班对急诊介入术中慢血流作用.docVIP

冠脉内替罗非班对急诊介入术中慢血流作用 　　【摘要】目的 观察冠脉内注射替罗非班对急诊直接冠脉介入治疗（primary percutaneous coronary intervention， PPCI）中慢血流的影响。方法 选择因急性心肌梗死（acute myocardial infarction，AMI）（缺血性胸痛发作2检验，以P 　　【关键词】冠脉内；替罗非班；慢血流；直接冠脉介入治疗 　　Effect of intracoronary tirofiban on coronary slow flow patients with acute myocardial infarction during primary percutaneous coronary intervention LI Xiang， WANG Chun-mei， ZHU Xiao-ling， AI Hui，ZHANG Qian. Department of Emergency Medcine，Beijing Anzhen Hospital，Beijing 100029， China 　　Corresponding author：WANG Chun-mei，Email：wangchunmei0214@ 　　【Abstract】Objective To investigate the effect of intracoronary application of tirofiban on coronary slow flow patients with acute myocardial infarction during primary percutaneous coronary intervention（PPCI）. Method It was a retrospective analysis of 187 patients with acute myocardial infarction treated with PPCI in the emergency department of Beijing Anzhen Hospital enrolled in this study from January， 2008 through January， 2011. The patients divided into 2 groups in terms of intra-coronary administration of tirofiban （tirofiban group） and intra-coronary use of nitroglycerol （control group） . Data were statistically analyzed by using SPSS 13.0 software . Categorical variables were analyzed using χ2 test and continuous variables were compared by t test. Results Between two groups， there were no differences in preoperative systolic pressure（P=0.245）， the rate of TIMI flow 3 （P=0.568）after PPCI and ST segment resolution（P=0.824）， LVEF（P=0.275） and in-hospital mortality （P=0.502）. Compared with tirofiban group， the systolic pressure was lower and the rate of using intra-aortic counter-pulsation was higher in control group. Although the incidence of slight bleeding in the control group was lower than that in the tirofiban group， no severe bleeding was observed in both groups. Conclusions The effect of intracoronary use of tirofiban was similar to that of nitroglycerol in terms of improving slow flow of coronary artery.It could s