cmi2014-chapter-8-lymphocytedevelopmentppt课件.pptVIP

4. Survival and maturation of lymphocytes in peripheral lymphoid tissues.外周淋巴组织中淋巴细胞的生存和发育 * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-23 不同淋巴细胞定位于外周组织的不同部位. 淋巴结的滤泡及生发中心(Germinal center)为B细胞区 淋巴结的T细胞区 * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-24 外周淋巴样组织的发育受淋巴样组织诱导细胞和TNF家族蛋白所调控. * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-25 淋巴细胞归巢（homing）至特定淋巴样组织是由趋化因子所介导. * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-26 淋巴细胞在外周首次遭遇足够量自身抗原时被删去或灭活. 外周耐受的形成机制: deletion、anergy