16免疫耐受PPT.pptVIP

2007口腔 Medical Immunology Clonal ignorance: T cells reactive to self antigen not represented in the thymus will mature and migrate to the periphery, but they may never encounter the appropriate antigen because it is sequestered in inaccessible tissues. Such cells may die out for lack of stimulus. Auto-reactive B cells that escape deletion may not find the antigen or the specific helper T-cells and hence not be activated and die out. Immunosupressive cytokines such as TGF-β and IL-10 secretion Contact between Treg cells and the responding T cells or APCs Activation induced cell death (AICD