免疫学 第十章 抗原递呈细胞及抗原PPT.ppt

第十章 抗原递呈细胞及抗原递呈 ;; 一、基本概念 ;;;;;;肺吞噬细胞吞噬大肠杆菌;;;;;二、抗原提呈;;1. 内源性抗原的加工;在蛋白酶体中的降解;酵母20s蛋白酶体的晶体结构;2. 内源性抗原肽的转运;;ER membrane;3. MHCⅠ类分子荷肽; ;4. 内源性抗原肽的递呈; ;;;MHCⅡ类途径。 分为抗原的摄取、加工、 MHCⅡ类分子的合成与转运、MHCⅡ类分子荷肽、递呈几个阶段。;1. 外源性抗原的摄取;Y;100;2. 外源性抗原的加工;Proteases produce ~24 amino acid long peptides from antigens Drugs that raise the pH of endosomes inhibit antigen processing;Activation of Cathepsin B at low pH;3. MHC Ⅱ类分子的生物合成和转运;Ii链的作用：;Need to prevent newly synthesised, unfolded self proteins from binding to immature MHC ;Invariant chain structure;A peptide of the invariant chain blocks the MHC molecule binding site. This peptide is called the CLass II associated Invariant chain Peptide (CLIP) ;4. MHCⅡ类分子荷肽;MHCⅡ类分子荷肽过程：;Endosomes;Removal of CLIP;5. 外源性抗原的递呈;HLA-DM catalyses the removal of CLIP;MIIC compartment sorts peptide-MHC complexes for surface expression or lysosomal degradation;native Ag; T cell response;