纳米技术在医学应用方面的全球市场分析报告.pptVIP

De s Po Co na les Mi Fu Na 18 HLC069A — Nanotechnology in Medical Applications: The Global Market The main types of nanoparticles currently available are listed in the table below. TABLE 2 MAIN NANOTECHNOLOGIES USED IN MEDICINE, WITH APPLICATIONS Technology Liposomes noparticles ymer-based Chitosan/lecithin nanoparticles Drug nanoparticles Description Vesicles composed of one or more phospholipid bilayer membranes Highly branched, monodispersed structures formed by the addition of shells of branched molecules to a central core Various polymers, used to produce biocompatible, biodegradable nanoparticles Nanoparticles coated, e.g., with polyethylene glycol to reduce recognition by the immune system Self-assembling nanoparticulate structures formed in aqueous media from block co-polymers Carbon formed in spherical cage-like structures Carbon, self-assembled in the presence of transition metal catalysts, into single walled cylinders Nanoparticles produced by self- assembly of chitosan and lecithin in ethanol Various technologies used to reduce size of drug crystals below100 nm Application Allow prolonged circulatory persistence, tissue targeting. Several liposomal products already marketed Delivery of therapeutics including small and large molecules into cells; cross biological membranes, e.g., blood-brain barrier Drug delivery; ligands can be attached to target certain cell types Drug delivery, enhanced circulatory persistence; delivery of DNA and antisense oligonucleotides Drug delivery for a range of therapeutic entities Can be developed to carry therapeutic agents Potential for drug delivery Drug delivery especially via the nasal route Improve solubility of poorly water soluble drugs Source: Adapted from Figure 1 in ?Tiny technology, huge future,? Scrip Magazine November 2005 In fact, many of the nanomedical technologies summarized in the table above already have been developed and commercialized, as follows. LIPOS