精神分裂症病理机制的研究进展PPT课件.ppt

精神分裂症病理机制的研究进展和治疗学发展;基本病理机制;有关发育异常;abnormal gene;RISK FACTOR 1 an enzyme is too slow ever since birth so it is hard to metabolize neurotransmitters when release is very fast;LIFE EVENTS;发育异常的表现;good neuronal selection;bad migration;;正确连线;;错误连线;神经传递异常的表现;hypothalamus;mesolimbic pathway;mesolimbic overactivity = positive symptoms of psychosis;meso-cortical pathway;primary dopamine deficiency;nigrostriatal pathway;tubero infundibular pathway;positive symptoms;精神分裂症的治疗机制;D2;pure D2 blocker;Increase in negative symptoms;EPSs;Blockade of receptors in the nigrostriatal dopamine pathway causes them to up-regulate;Prolactin levels rise;H1;constipation;= acetylcholine;= D2 blocker;= anticholinergic;H1 INSERTED;drowsiness;1;5HT2A;5HT7;5HT-DA Interactions;conventional antipsychotic;serotonin-dopamine antagonist;conventional antipsychotic;serotonin-dopamine antagonist;5HT7;5HT6;5HT7;Are Antipsychotics with Multiple Therapeutic Mechanisms Better than Selective Dopamine 2 Antagonists?;DA部分激动剂或DA稳定剂;hypothalamus;精神分裂症的多巴胺假说;多巴胺部分激动的原理;agonist;FULL AGONIST -- light is at its brightest;PARTIAL AGONIST -- light is dimmed but still shining;NO AGONIST -- light is off;PARTIAL AGONIST -- light is dimmed but still shining;神经退行性变;“pruning” out of control;神经退行性变－－细胞死亡;abnormal gene product;over excitation due to glutamate;excess calcium activates enzyme;enzyme produces free radical;free radicals begin destroying the cell;finally, free radicals destroy the cell;10-20;精神分裂症治疗;免疫异常和免疫调节剂治疗; Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+ cells in medication-free patients with schizophrenia (Zhang, Zhou et al, Journal of Psychiatric Research 2002) 研究发现精神分裂症患者存在IL-2 产物生成降低，与T细胞数目减少， IL-2分泌减少有关 ; ? Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology (Zhang, Zhou et al, Schizophrenia Research 2002) 研究进一步发现未服抗精神病药物的不同亚型精神分裂症患者细胞因子改变不同 ; Changes in serum interleukin-2, -6, and -8 leve