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肾动脉狭窄支架术现状课件_1
Renal stenting in renal artery stenosis----contented and uncontented 肾 动 脉狭窄支架术 ARAS 90% FMD 10% Haemodynamics: 50% Renal perfusion pressure reduction 70% RPP75-85mmHg, autonomic regulation lose Pathology: Glomcrulus:arteriosclerosis, mesenterium proliferation, Nephric tubule:epithelial cells denudation、apoptosis,Focal necrosis, Renal interstitium:Inflammatory cell infiltration、fibrocyte proliferation End stage :renal atrophy Develop to total occlusion within 5 years 15% Deterioration gradually within 5 years 10-20% Develop to ESRD annually 5-15% 3-year mortality in Pt. with ESRD on dislysis 50% Survival of ARAS Pt. with ESRD on dislysis: 5-year 18% 10-year 5% Renal function: improement: GFR increse 15% /Scr decrease 0.2mg/dL stable: GFR change15% / Scr change 0.2mg/dL ineffective: GFR decrease 15% / Scr increase 0.2mg/dL benefit: Improement or stable Blood pressure: cure: SBP140mmHg and DBP90mmHg, without any anti-hypertension drugs, improement: SBP140mmHg and DBP90mmHg, or, DBPdecrease 15mmHg with similar or less anti-hypertension drugs ineffective: BP change not meet the above standard benefit: cure and improvement nephron redunction volume-dependent hypertension:(Bil RAS/renal dysfunction) renin-dependent hypertension:(uni RAS) sympathetic nervous system vasoactive substance secreted from kidney:natriuretic hormone vasopressin Renal arteriolar sclerosis in benign hypertension Early stage:hyalinization in afferent glomerular arteriole and arteria interlobulares advanced stage:glomerulus, nephri
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