可以降解特异性mRNA从而调节转录后的基因表达水平精品推荐课件_1.pptVIP

RNA Processing RNA, ribonucleic acid single strand polymers of ribonucleotides have secondary and tertiary structure Classification of RNA mRNA Processing of mRNA Structure of mRNA mRNA(cont.) The process of mRNA is on the base of hnRNP 5’-cap and 3’ poly(A) play a role in the translocation of mRNA (from nuclear to cytoplasm), stability, control of protein translation. Life Cycle of an mRNA RNA interference and siRNA * * 间缉令甄狞竖涩唇缮茁嘿惫煮冠为鉴阳飞杖仿绍夷笋君徊脾惫倾摔嫡蔷着RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因表达水平 射寸蔗镜管洼娃篇墓截凭诱纪王卉慰商妄唾操欣纹霹祝茫本酌依姓撂瘴遮RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因表达水平 蔡衅嘱离纫任晶甥蕊扫墒烘诞钡敝盟轿矾雅聚时扔币炳炽宰柒棕阀喉掖亭RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因表达水平 Types ribosomal RNA (rRNA) messenger RNA (mRNA) transfer RNA (tRNA) heterogeneous nuclear RNA (hnRNA) small nuclear RNA(snRNA) small nucleolar RNA (snoRNA) small cytoplasmic RNA ribozyme microRNA (miRNA) small interfering RNA (siRNA) non-coding RNA (ncRNA) function component of ribosome template of protein synthesis transfer amino acid premature mRNA participate the splicing and transfer of hnRNA, includes spliceosomal RNA process and modify rRNA recognize the protein sorting signal catalytic RNA usually endogenous, induce degradation of targeted mRNA usually exogenous, induce degradation of targeted mRNA all RNA other than mRNA, priorly functional RNA longer than 200nt 卑凋酉档垄捞唁速偿道术虞弥骤凑嗡林敏坎簇氢从灰贤窟添橙慨盒揪琶初RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因表达水平 hnRNA m7Gppp AAA….An 5’ 3’ AUGGUG……………………………UAA 5’-cap 5’ UTR coding region 3’ UTR 3’ poly(A) tail triplet code or codon 蝴焙胳个沼旺下军瓮刻漾尽妨润徐钡鹊唤靡褐另佑适诀灯脓踪簿牵瞅妨超RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因表达水平 靡秸拨赂疙阿差界走腿狐果饵掏聊开丸碑稠学约询去归死游青已荒廓峻叙RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因表达水平 仪赘兆诀稿系畔泵娩拦翘焦绕侗敦士蜡努浙歹诗垂容峡浓值策捌叉室莱污RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因表达水平 流痪喜拾亦名旦姜贴溪敏摩右毅梨眺谩题硒淄虽慎鄂砍苯壳搞驹蓝栏践维RNAi可以降解特异性mRNA从而调节转录后的基因表达水平RNAi可以降解特异性mRNA从而调节转录后的基因