爱赛平在鼻炎治疗中的作用课件.ppt

在治疗变应性鼻炎方面，这张幻灯片总结氮卓斯汀分别与氯雷他定、非索非那定和西替利嗪的对比临床试验结果。大家可以看出，氮卓斯汀明显优于氯雷他定、非索非那定。对于氯雷他定或非索非那定疗效不理想的患者，换用爱赛平与安慰剂比较显示，爱赛平能使患者的症状评分改善22%或19%，而安慰剂组的症状评分改善只有11%，两组之间有显著差异。 下面将详细介绍有关ACT1和ACT2的数据，也就是氮卓斯汀和西替利嗪的比较结果。 * ?研究结果显示：纵坐标表示总鼻部症状积分的平均改善程度。可以看出，氮卓斯汀治疗组患者症状改善趋势要明显优于西替利嗪组 。其中在ACT1中有统计学意义，但在ACT2中仅有这种趋势。 其中，氮卓斯汀用黄色表示，西替利嗪用绿色表示。 Key Message: Azelastine outperformed Cetirizine in two double-blind well controlled clinical trials. To compare the efficacy and tolerability of Azelastine HCl Nasal Spray (ASTELIN) versus the leading prescription antihistamine, Cetirizine (Zyrtec) two trials in moderate-to-severe seasonal allergic rhinitis (SAR) patients were conducted Patients treated with azelastine nasal spray had a 27% greater improvement from baseline in TNSS over cetirizine in ACT I, which was statistically significant (P=.015) (Corren J et al., 2005; Berger W et al., 2006) In ACT II, azelastine nasal spray demonstrated a 22% greater improvement from baseline in TNSS over cetirizine, which did not attain statistical significance (Berger W et al., 2006) Other notes: ACT I and ACT II: In both treatment groups, all individual symptoms improved significantly from baseline (P.05) Although the ACT trials were not statistically powered to detect significant differences for individual symptoms, azelastine nasal spray produced improvements over cetirizine + placebo saline nasal spray for all four symptoms in ACT I and ACT II (see data below): Corren J, Storms W, Bernstein J, et al. Effectiveness of Azelastine Nasal Spray Compared to Oral Cetirizine in Patients with Seasonal Allergic Rhinitis. Clin Ther. 2005;27:543-553. Berger W, Hampel F, Bernstein J, Shah S, Sacks H, Meltzer EO. Impact of azelastine nasal spray on symptoms and quality of life compared to cetinizine oral tables in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2006;97:375-381. * 此外，氮卓斯汀治疗组患者在生活质量方面也存在优于西替利嗪组的趋势。 Key Message: Azelastine outperformed Cetirizine in two double-blind well control