血友病的治疗和风险版本李振宇课件.pptVIP

“5大点！”包括哪些内容 坚持锻炼，控制体重，保护关节 经常锻炼可以强健筋骨，强壮的肌肉可以保护 关节面首损伤。可以向血友病诊疗中心的医生 咨询适合你的锻炼项目。 定期接受血清病毒学和抑制物检测 虽然现在的凝血因子产品比过去更安全，但是定期接受血清病毒学检测仍非常重要。定期检查可以保护自己，还能帮助医学界发现可能发生的问题。 综合治疗的效果 平均寿命（岁） 13-40 65 住院天数/年 12-15 1 关节疾病患病率 70-80% 5% 年门诊访问次数 12-30 0-6 失业率 35-90% 15% 缺少综合治疗 综合治疗 Evatt B, Haemophilia 2006; 12 (suppl 3):13-21 集结社会力量 实现血友病患的心愿 像正常人一样生活 享受免费的治疗 远离痛苦和残疾 * * * HBV was identified and documented in the mid to late 1960s.10 This discovery would unfortunately become particularly meaningful for patients with hemophilia in the next decade Beginning in the 1970s, thousands of plasma donations were being pooled in plasma concentrates, and high-potency dried replacement factors made home infusion possible.9,11 The first licensed antihemophilic factor (AHF) was Hemofil?.12 The development of plasma concentrates revolutionized the treatment of hemophilia and permitted many patients a nearly normal lifestyle9 Unfortunately, the pooling of large numbers of plasma donations for plasma concentrates of FVIII had a terrible consequence. By the late 1970s, 75% to 95% of patients with hemophilia were HBV-positive.13 In addition, non-A–non-B hepatitis, later identified as hepatitis C, was also present in a majority of patients9 In 1982, HIV was identified for the first time in 3 hemophilia patients. By the mid to late 1980s, more than three fourths of patients with hemophilia were HIV positive,9 and in the early 1990s, the vast majority of patients with hemophilia were infected with HCV14 The first in a long series of innovations to reduce contamination in FVIII concentrates began in the mid and late 1980s. Heat-treated plasma concentrates were introduced in 1984, followed by enhanced viral inactivation techniques and expanded donor screening in the late 1980s10 Slide 20 Internal use statement goes here. 甲型血友病的治疗和风险 李振宇 徐州医学院附属医院 内容提要 血液制品的安全性 2 甲型血友病的替代疗法 3 1 Ⅶ、Ⅷ、Ⅸ Ⅲ（组织因子）Ⅳ（Ca2+)、Ⅴ Ⅰ(纤维蛋白原) Ⅱ (凝血酶原） Ⅹ、Ⅺ、Ⅻ、XⅢ 、vWF 参与凝血的凝血因子 血友病是一种出血性疾病 血友病 血