Th1Th2型细胞因子及免疫状态在支气管哮喘患儿治疗前后变化.docVIP

Th1Th2型细胞因子及免疫状态在支气管哮喘患儿治疗前后变化 　　[摘要] 目的 探讨Th1/Th2型细胞因子及免疫状态在支气管哮喘患儿治疗前后中的变化。 方法 选取榆林市儿童医院2011年5月～2013年3月收治的48例支气管哮喘患儿为研究对象（研究组），另外选取同期进行健康体检的48例健康儿童作为对照组，检测两组研究对象治疗前及治疗后1、4周时Th1细胞因子[白介素-2（IL-2）、干扰素-γ（IFN-γ）]、Th2细胞因子[白介素-4（IL-4）、白介素-5（IL-5）、白介素-10（IL-10）、白介素-13（IL-13）]和免疫指标，并进行统计学比较。 结果 治疗前研究组患儿IL-2、IFN-γ和IL-10均明显低于对照组（t = 8.52、11.84、6.57），IL-4、IL-5和IL-13明显高于对照组（t = 12.98、15.87、11.88），差异均有统计学意义（P 0.05）。治疗前研究组患儿CD3+、CD4+及CD4/CD8均明显低于对照组（t = 9.23、10.52、8.11），而CD8+则高于对照组（t = 9.61），差异有统计学意义（P 0.05）。研究组各时间段Th1、Th2细胞因子比较，差异有统计学意义（F = 1.96、3.19、3.25、4.01、2.15、1.81，均P 　　[关键词] Th1/Th2型细胞因子；免疫状态；支气管哮喘 　　[中图分类号] R562.25 [文献标识码] A [文章编号] 1673-7210（2013）11（c）-0081-03 　　Changes of Th1/Th2 type cytokines and immune status in children with bronchial asthma before and after treatment 　　XUE Tao 　　Department of Pediatrics， Childrens Hospital of Yulin City， Shaanxi Province， Yulin 719000， China 　　[Abstract] Objective To explore the changes of Th1/Th2 type cytokines and immune status in children with bronchial asthma before and after treatment. Methods 48 cases of children with bronchial asthma who were treated in c Childrens Hospital of Yulin City from May 2011 to March 2013 were selected as the research group， in addition， 48 healthy children who were given health physical examination were selected as the control group， the Th1 cytokines [including interleukin-2 （IL-2） and gamma interferon-γ （IFN-gamma）]， the Th2 cytokine [including interleukin-4 （IL-4） and interleukin-5 （IL-5） and interleukin-10 （IL-10） and interleukin-13 （IL-13）] and immune indexes in both groups before and after 1， 4 weeks treatment were detected and statistical compared. Results The IL-2， IFN-γ and IL-10 in research group before treatment were lower than those in control group （t = 8.52， 11.84， 6.57）， and IL-4， IL-5 and IL-13 in research group before treatment were higher than those in control group （t = 12.98， 15.87， 11.88）， the differences were statistically significant （P 0.05）. The CD3+， CD4+ and CD