分析手足口病重症危险因素及临床治疗方案.docVIP

分析手足口病重症危险因素及临床治疗方案 　　首都医科大学附属北京地坛医院感染二科，北京 100015 　　[摘要] 目的 分析手足口病（HFMD）重症的危险因素及临床治疗方案。 方法 选取首都医科大学附属北京地坛医院于2010年7月～2012年7月收治的50例HFMD重症患者作为观察组，50例HFMD轻症患者作为对照组，比较两组患者的临床特点，通过多因素分析筛选出HFMD重症的危险因素。 结果 对照组和观察组患者在年龄 39℃大于3 d、血糖 9 mmol/L、意识障碍、精神差、神经反射异常、外周血WBC 12×109/L方面，差异具有统计学意义（P 7 d、口腔溃疡、肌酸激酶升高方面，二者的差异无统计学意义（P 0.05）； HFMD重症的独立相关因素包括年龄、体温 39℃大于3 d、血糖 9 mmol/L、精神差、神经反射异常；观察组患者的治愈率为68%，病死率为4%。 结论 早期检测HFMD重症的危险因素并进行及时的对症治疗可降低手足口病病死率。 　　[关键词] 手足口病重症；危险因素；临床治疗方案 　　[中图分类号] R512.5 [文献标识码] A [文章编号] 1673-7210（2013）11（b）-0063-03 　　The risk factors and clinical treatment programs of severe hand-foot-mouth disease 　　LU Lianhe CHEN Zhihai XU Yanli SONG Rui WANG Aibin LI Xingwang 　　The Second Department of Infection， the Affiliated Beijing Ditan Hospital of Capital Medical University， Beijing 100015， China 　　[Abstract] Objective To analyze the risk factors and clinical treatment programs of severe hand-foot-mouth disease （HFMD）. Methods 50 cases with severe HFMD from July 2010 to July 2012 in the Affiliated Beijing Ditan Hospital of Capital Medical University were selected as the observation group， and other 50 patients with mild HFMD were selected as the control group， then the clinical characteristics of the two groups were compared and the risk factors of severe HFMD were screened through multi-factor analysis. Results The age 39℃ in more than three days， blood glucose 9 mmol/L， disturbance of consciousness， the spirit of poor dysreflexia， peripheral blood WBC 12×109/L in the two groups were found had statistically significant difference （P 7 d， mouth ulcers， rise of creatine kinase between patients in the two groups were found had no statistically significant difference （P 0.05）； the independent associated factors of severe HFMD included age， body temperature 39℃ for more than 3 d， blood glucose 9 mmol/L， poor spirit dysreflexia； the cure rate of patients in the observation group was 68%， and the mortality rate was 4%. Conclusion Detecting the risk factors fo