_adaptation to visual blurring a 3T functional MRI 皮质适应视觉模糊3T功能磁共振成像课件.ppt

* * * * * * * * * * * CORTICAL ADAPTATION TO VISUAL BLURRING: A 3T FUNCTIONAL MRI COMPARISON BETWEEN CORRECTED MYOPIA AND EMMETROPIA Nguyen T.H.1, Stiévenart J.L.1, Istoc A.1, Girmens J.F.2, Yoshida M.3, Baranton K.4, Habas C.1, Abanou A.1 1 - Department of Neuro-Imaging, C.H.N.O. des 15-20, Paris, France 2 - Centre d’Investigations Cliniques (CIC), C.H.N.O. des 15-20, Paris, France 3 - Department of Ophthalmology, Jikei university School of Medicine, Tokyo, Japan 4 – Vision Science Department, RD Optics, Essilor, Paris, France XIX Symposium Neuroradiologicum The World Congress of Diagnostic Therapeutic Neuroradiology Bologna, Italy, 5 October 2010 Purpose To investigate a difference of the visual cortex response in corrected myopic patients and normal subjects, when submitted to blurred and unblurred images Materials and methods (1) We explored 15 subjects from 18 to 35 years of age 9 subjects with emmetropia (within – 0.75 and + 1 diopters) 6 subjects with corrected myopia (from – 6 to – 1 diopters) Initial ophthalmological examination (C.I.C.) Anisometropia below 1 diopter No other ophthalmological pathology Visual correction reaching 20/20 in ETDRS Chart R Materials and methods (2) Functional exploration using a 3T MRI device (G.E.H.C., Milwaukee, U.S.A.) Spatial resolution alteration: image unblurring– blurring Cortical retinotopic locations FLOU – NET : scènes Unblurring : Scenes FLOU – NET : lettres Blurring : Optotypes Materials and methods (3) Cortical response through statistical evaluation : individual and group analysis Statistical Parametric Mapping (SPM 8) ? BrainVoyager ? Time response at image resolution change Individual analysis - Emmetropia Unblurring Blurring S O S O Individual analysis - Corrected myopia  Unblurring Blurring S O S O Individual analysis - Emmetropia Unblurring Blurring Individual analysis - Corrected myopia  Unblurring Blurring Group analysis - Unblurring Emmetropia Corrected myopia Group