_Syndrome Comparison of Assessments with 干燥综合征的评估与比较课件.ppt

Sjogren’s Syndrome: Comparison of Assessments with Quantitative Salivary Gland Scintigraphy and Contrast Sialography J Nucl Med 2000; 41: 257-262 Sjogren’s Syndrome Autoimmune disease Affecting salivary and lacrimal glands Xerostomia (the most common oral symptom). The complaints of patients do not necessarily reflect the severity of their salivary gland disease. Sjogren’s syndrome Contrast sialography Gold standard in the diagnosis of the syndrome Invasive method (disadvantages and complications) Salivary gland scintigraphy with 99mTc-sodium pertechnetate Evaluate salivary gland function in xerostomic pateints Easy and noninvasive method (bilateral parotid and submandibular glands) No standard method for assessing Sjorgren’s syndrome has been established No report has deal with the relationships between quantitative scintigraphic parameters and sialographic findings In this study Comparing quantitative parameters of salivary gland scintigraphy and sialographic findings in Sjogren’s syndrome. Determining useful scintigaphic parameters for evaluation of salivary gland disease and calculated an equation to correlate the sialographic stage with the scintigraphic parameters. MATERIALS AND METHODS Patients 116 consecutive patients (105 woman, 11 men; age range, 18-77 y; mean age, 54 y) who had xerostomia and were clinically suspected of having Sjogren’s syndrome. Sjogren’s syndrome was diagnosed in 50 of the 116 patients (contrast sialography as gold standard), and confirmed by complete P.E., laboratory testing, labial salivary gland biopsy (all showed histopathological changes of grade 1 or greater). Imaging Examination Dynamic salivary scintigraphy Performed after intravenous injection of 370 MBq 99mTc-sodium pertechnetate Γ camera and analysis system UR and MA: quantity of accumulation MS: quantity of secretion. Tmax: velocity of accumulation and spontaneous secretion. Tmin: velocity of secretion after stimulation Imaging examination Contrast sialography A ca