老年急性缺血性脑梗死患者血清N端脑钠肽前体水平变化及意义.docVIP

老年急性缺血性脑梗死患者血清N端脑钠肽前体水平变化及意义 　　[摘要] 目的 分析老年急性缺血性脑梗死患者N端脑钠肽前体（NT-pro-BNP）水平的变化，探讨NT-pro-BNP与老年缺血性脑梗死的关系。 方法 连续选取本院的老年急性缺血性脑梗死患者85例，健康体检者（对照组）30例，在入院2 d内测定各组血清NT-pro-BNP水平及NIHSS评分，并进行组间比较。按TOAST分为心源性脑梗死组（27例），非心源性脑梗死组（58例），按梗死面积大小分为大面积梗死（32例）组、小面积梗死（53例）组。 结果 脑梗死组血清NT-pro-BNP值显著高于正常对照组（P 　　[关键词] 急性缺血性脑梗死；N端-脑钠肽前体；脑梗死；老年人 　　[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721（2013）11（a）-0046-03 　　Variation and significance of N-terminal pro-brain natriuretic peptide levels in serum in elderly patients with acute ischemic stroke 　　WANG Jin-ding WAN He-bin WAN Shan-shan WEN Shi-fang PENG jing-hua 　　Department of Neurology， the First People′s Hospital of Jiujiang City in Jiangxi Province， Jiujiang 332000， China 　　[Abstract] Objective To analyze the levels of N-terminal pro-brain natriuretic peptide （NT-pro-BNP） in patients with acute ischemic stroke and probe into the relationship between NT-pro-BNP and ischemic stroke of elderly. Methods 85 patients with acute ischemic stroke admitted into our hospital and 30 healthy participants （control group） were selected. The levels of NT-pro-BNP from serum and national institutes of health stroke scale （NIHSS） were tested within 2 days after being hospitalized in each group. The outcomes would be compared. According to TOAST， these patients were divided into cardiac cerebral infarction group （n=27） and non-cardiac cerebral infarction group （n=58）. If based on infarct size， they were divided into large area infarction group （n=32） and small area infarction group （n=53）. Results The level of NT-pro-BNP in the cerebral infarction group was remarkably higher than that in the control group （P 　　N端脑钠肽前体（N-terminal pro-brain natriuretic peptide，NT-Pro-BNP）是心脏、脑等分泌的利钠肽成员之一，其在心力衰竭患者的诊断、治疗评估和预后判断方面都有重要的临床意义，已得到专家共识，现成为国际公认的诊断心力衰竭的血浆标志物。近年来，NT-Pro-BNP在脑血管疾病研究中越来越受到人们的关注并已成为研究的热点。而NT-pro-BNP在老年急性缺血性脑卒中患者发病中的作用及其机制在国内外文献中报道较少。本文探讨老年急性缺血性脑梗死患者血清NT-Pro-BNP浓度的变化及临床意义，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选择本院神经内一科2012年8月～2013年6月住院的老年急性缺血性脑梗死患者85例，男48例，女37