迁延性腹泻患儿血尿锌水平变化及对其补锌临床效果评价.docVIP

迁延性腹泻患儿血尿锌水平变化及对其补锌临床效果评价 　　[摘要] 目的 探讨迁延性腹泻患儿血尿锌水平的变化及对其补锌的临床效果。 方法 收集2008年3月～2013年3月入住本院的100例迁延性腹泻患儿及同期于本院保健科体检的健康儿童50例的尿及末梢血，采用多通道原子吸收光谱法对血、尿锌水平进行检测、分析。将患儿组按照抽签方法随机均分为非补锌组与补锌组，两组均给予补充水电解质、纠正酸中毒、微生态疗法以及支持疗法等常规治疗，补锌组在此基础上口服赖氨葡锌颗粒。比较患儿组与健康对照组血、尿锌水平，补锌组与非补锌组患儿的治疗效果、止泻时间及平均住院时间。 结果 患儿组血锌、尿锌及尿锌/尿肌酐水平均明显低于健康对照组（P 　　[关键词] 迁延性腹泻；血尿锌；补锌；临床效果 　　[中图分类号] R725.7 [文献标识码] A [文章编号] 1674-4721（2013）11（b）-0016-03 　　Hematuria zinc level change in children with persistent diarrhea and the clinical efficacy evaluation of zinc supplementation 　　CAO Zhe-lian 　　Department of Pediatrics，People′s Hospital of Cili County in Zhangjiajie City，Hunan Province，Cili 427200，China 　　[Abstract] Objective To analyze the hematuria zinc level change in children with persistent diarrhea and to evaluate the clinical efficacy of zinc supplementation.Methods 100 patients with persistent diarrhea treated in our hospital from March 2008 to March 2013 and 50 healthy children from health examination in our Health Division over the same period were collected and then detected and analyzed their zinc levels by multi-channel atomic absorption spectrometry.Patients were equally and randomly divided into zinc group and non-zinc group by lot.The two groups were given water and electrolyte supplement，corrected acidosis，microbial therapy and supportive therapy and other conventional treatment.Patients in zinc group were added with oral lysine and zinc gluconate granules.Comparisons of blood and urine zinc levels between the patient′s group and the healthy control group and the treatment effects，diarrhea-stopping time and average length of stay between the zinc and non-zinc group were made.Results The patients group had significantly lower blood Zn，urinary Zn and urinary Zn/Cr level than that of the healthy control group respectively （P 　　[Key words] Persistent diarrhea；Hematuria zinc；Zinc supplementation；Clinical effect 　　小儿腹泻是一组多病原以及多因素引起大便次数明显增多及大便性状出现明显改变为主要特征的消化道综合征，是我国婴幼儿人群中较为常见的一种疾病[1]。近年来，使用口服补液盐及治疗腹泻的方法