建立视神经挤压伤地标准方法Yasargil(脑)动脉瘤夹.docVIP

A standardized method to create optic nerve crush: Yasargil aneurysm clip 建立视神经挤压伤的标准方法:Yasargil(脑)动脉瘤夹 Levent Sarikcioglu a,*, Necdet Demir b,c, Arife Demirtop c a Department of Anatomy, Akdeniz University, Faculty of Medicine, 07070 Antalya, Turkey a土耳其, 07070 Antalya, Akdeniz大学医学院, 解剖部 b Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, 07070 Antalya, Turkey b 土耳其, 07070 Antalya, Akdeniz大学医学院, 组胚部 c Electron Microscopy Unit (TEMGA), Akdeniz University, Faculty of Medicine, 07070 Antalya, Turkey c 土耳其, 07070 Antalya, Akdeniz 大学医学院, 电镜部 Received 4 August 2006; accepted in revised form 18 October 2006 Available online 8 December 2006 2006-8-4收稿；2006-10-18校后发表；2006-12-8在线发表 Abstract It is often difficult to compare results obtained by different investigators on nerve compression injuries, owing to differences in method of pressure application and noncomparable pressure levels. In the present study, we described a new method to crush the optic nerve by using a specially designed and commercially available device. We think that standardization of the compression methods is necessary to compare interlaboratory results. _ 2006 Elsevier Ltd. All rights reserved. 摘要：由于不同研究者建立神经挤压伤过程中使用方法不同, 压力程度不同, 通常要比较所得出的结果很困难。现在，描述一种新的建立神经挤压伤的方法，此方法采用的设备专门设计且市面有售。我们认为，为了比较各项试验结果，非常有必要将挤压伤的方法标准化。 Keywords: Yasargil aneurysm clip; crush injury; optic nerve 关键词：Yasargil （脑）动脉瘤夹；挤压伤；视神经 Introduction 1．引言 The optic nerve of the rat is a very vulnerable structure (Gellrich et al., 2002). Isolated position of the optic nerve allows the scientist to create lesions conveniently, without damaging other parts of the brain. Another advantage of the optic nerve lesion model is that recovery of the function can be studied in a well-defined anatomical system with specific tests of visual behavior (Sabel and Aschoff, 1993). 鼠视神经结构非常易损伤（Gellrich 等，2002）。视神经位置孤立，这使科学家很方便建立损伤，不会损坏脑的其它部分。视神经损害模型另一优势在于可以在确定的解剖系统中通过针对视觉反应的特定试验研究其功能恢复情况（Sabel and Aschoff, 1993）。 Trauma t