达比加群临床用药建议 ppt课件.ppt

病历分析(1) 病历分析(2) Impact of dabigatran on a large panel of routine or specific coagulation assays aPTT = activated partial thromboplastin time; HTI = Hemoclot Thrombin Inhibitor; ECA = ecarin chromogenic assay; ECT = ecarin clotting time(蛇静脉酶凝结时间); TGA = thrombin generation Assay; TT = thrombin time; PT = prothrombin time In patient taking 150 mg DE bid regimen, an aPTT above 80 sec at trough (corresponding normally to a Ctrough = 200 ng/ml) is correlated with an increased risk of bleeding This cut-off is reduced to 45 sec (corresponding normally to a Ctrough = 67 ng/ml) for patients taking