【医药健康】口腔粘膜溃疡类疾病.ppt

口腔粘膜溃疡类疾病Oral Ulcerative diseases I. Introduction Ulcers are one of the most common types of lesions seen in oral mucosa. 2. The difference between ulcer and erosion. ulcer Recurrent Aphthous Ulcer 1.Preface ? Name recurrent aphthous ulcer RAU recurrent aphthous stomatitis RAS recurrent oral ulcer ROU ? Typing Lehner’s classification minor aphthous ulcer （MiAU） major aphthous ulcer （MjAU） herpetiform ulcer （HU） ? Characteristic recidivity self-healing periodicity 2. Etiology unknown ? immunity : cellular immunity, humoral immunity, complement, autoantibody ? heritage ? infection ：HSV ? environment: psychology 3. Clinical features minor aphthous ulcer major aphthous ulcer herpetiform ulcer disease-process 5. Diagnosis 6. Differential diagnosis Comparison 7. Treatment principle：symptomatic treatment Evaluation of curative effect Topical application of a steroid ointment reduces discomfort and decreases the duration of the lesions. Topical anesthetics, antibiotics, mouthwashes, etc., have been used. In severe cases, intralesional steroid injection or systemic steroids in a low dose (10-20 mg prednisone) for 5-10 days reduce the pain dramatically. III. Beh?et’s disease 1. Preface Hulusi Beh?et (1937) Beh?et’s disease is a chronic multisystemic inflammatory disorder of uncertain cause and prognosis. 2. Etiology Unknown 3. Clinical features 1) oral mucosa: minor aphthous ulcer 2) genital lesion: ulcer 3) skin lesions: erythema nodosum, epifolliculitis, pustule after needling 4) ocular lesions: conjunctivitis, recurrent iritis 5) others systems: joint, digestive, cardiovascular, nervous, respiratory, urinary Beh?et’s disease 4. Pathology ： Histopathologic changes consist of a perivascular mononuclear cellular infiltrate, endothelial cell swelling or