义务教育11-3.pptVIP

The reaction conditions needed for aldol dehydration are often only a bit more vigorous (slightly higher temperature, for instance) than the conditions needed for the aldol condensation itself. As a result, conjugated enones are often obtained directly from aldol reactions without ever isolating the intermediate β-hydroxy carbonyl compounds. The mechanism of the Claisen reaction is similar to that of the aldol reaction. The reaction involves the nucleophilic addition of an ester enolate ion to the carbonyl group of a second ester molecule. The only difference between an aldol condensation and