锥虫（Trypanosoma）表面抗原转换机制课件_2.ppt

锥虫(Trypanosoma)表面抗原转换机制 ;一、锥虫抗原变异现象;二、锥虫表面变异抗原（VSG）的组成;三、锥虫VSG表达的遗传基础;;四、锥虫表面抗原（VSG）转换机制;;; 五、锥虫VSG变异规律;六、锥虫VSG基因变异与宿主的关系; 七、结语;谢 谢!;Fig1. Minichromosomes (red) and large chromosomes (yellow) exhibit different positional dynamics during mitosis. DNA(blue) ;Fig2：Schematic representation of a trypanosomal variant surface glycoprotein(VSG) gene expression site.Modelled after Revelard et al.and Lips et al.The flag indicates the promoter ,the number in the box indicate the expression site-associated genes (ESAGs), V indicates the VSG gene,and End indicates the chromosome terminus.The enlargements show feature of ESAG6 and ESAG7,which encode subunits of the Tf-R.;Fig2：Schematic representation of a trypanosomal variant surface glycoprotein(VSG) gene expression site.Modelled after Revelard et al.and Lips et al.The flag indicates the promoter ,the number in the box indicate the expression site-associated genes (ESAGs), V indicates the VSG gene,and End indicates the chromosome terminus.The enlargements show feature of ESAG6 and ESAG7,which encode subunits of the Tf-R.;Fig2：Schematic representation of a trypanosomal variant surface glycoprotein(VSG) gene expression site.Modelled after Revelard et al.and Lips et al.The flag indicates the promoter ,the number in the box indicate the expression site-associated genes (ESAGs), V indicates the VSG gene,and End indicates the chromosome terminus.The enlargements show feature of ESAG6 and ESAG7,which encode subunits of the Tf-R.;1I0J0AQLSi*fjeBANpO5Cu0yS(%lq6jvTwt%axS5jboY4qBQV!4GYytShw$6yYx(NB)l)RNv2zF*5#2!r(sU8ZgRmc-d4qWGYYM!a%Q2iKecc#5z$fyVODO5oLWJR+)i!jZIZ$-twp2yE$x#%(L-KZi+PHHU!jT2mEj4q!M!dnfSQF3yf)U4o43k8qYcfiHHrCIxVZgueDdkJc3GND8XW5kiJcXSf1n#%5vp0fwIfYqCCIaFRTbqTqRK*8)nBbC8y++a(31g6(h$QW!X(RtwkKv9Bf3eFC+IViI+mA-V06gJi#Pg+90UhPEBo!vI%Lz6GKki32jBWkXz04l49$rgZlgPk0YrHl95Blcamoi#buBiGp76JgDF*8cIga1)APJ3OhsTA4fjC*(f98IZjSLRbUwD+J6LN1qk7NU#4t(T2(hEw)BABG-XEMwUV-K!v6NCvTMbsr7+LaMS75M8J(-eEq9nHt2w*C)qRLe6kIsUXb9(qsYQ3qib1Fxb1*Goz