局部麻醉英文版 pt课件.pptVIP

Bupivacaine pKa 8.1 Plain aq soln .25, .375, .5% @ pH 4.5-6 If with adrenalin pH 3.5-5.5 Potency 8 Protein binding 95% lipid solubility than lidocaine T1/2? adult 3.5hr, neonate 8.1-14hr Amide link LA Prod prolonged anaesthesia with slower onset Add adrenalin - ?toxicity, h/e no change in duration Post op analgesia : IC 7hr, EA 3-4hr Epid/caudal peak [plasma] 30-45 min Lower foetal/maternal ratio cf lidnocaine (! Protein binding) Max dose : plain/with adrenalin 2 mg/kg Ropivacaine Chemical analogue of bupivacaine The molecule is designed to modify the spesific cardiotoxicity associated w