Zn-HApLGA纳米纤维膜的制备与研究.docxVIP

Zn-HAp/PLGA纳米纤维膜的制备与研究论文设计者：***指导教师：***专业：生物医学工程论文方向：生物材料二0一五年五月学术诚信声明本人所呈交的毕业论文，是在导师的指导下，独立进行研究工作所取得的成果，所有数据、图片资料均真实可靠。除文中已经注明引用的内容外，本论文不包含任何其他人或集体已经发表或撰写过的作品或成果。对本论文的研究作出重要贡献的个人和集体，均已在文中以明确的方式标明。本毕业论文的知识产权归属于培养单位。本人完全意识到本声明的法律结果由本人承担。本人签名： 日期： Zn-HAp/PLGA纳米纤维膜的制备与研究Prepare and study on Zn-HAp/PLGA nanofiber membrane专业：生物医学工程本科生：***指导教师：***摘要羟基磷灰石与人体骨组织具有相似的结构,因而引起了科研工作者的关注。随着对羟基磷灰石研究的深入，科研工作者发现它具有良好生物相容性，可以引导骨的生长，能够与骨组织形成牢固的骨性结合。因此，羟基磷灰石常用于骨修复和替代材料。PLGA是一种可降解的高分子有机化合物，具有良好的生物相容性、无毒，在组织工程中常作为支架材料来进行细胞的培养，为细胞生长提供三维空间。因此，本文以羟基磷灰石与PLGA为原料制备了一种复合材料，以期应用到骨组织工程中。本文以、、为原料，利用化学沉淀法制备出锌掺杂的纳米羟基磷灰石，再用静电纺丝法制备锌掺杂羟基磷灰石纳米粒与PLGA复合纤维膜并用FTIR、SEM对纤维膜进行表征。SEM结果表明羟基磷灰石与PLGA的复合材料在纤维形貌上的表现更为出色。关键词：锌掺杂羟基磷灰石；PLGA；静电纺丝；骨组织工程Prepare and study on Zn-HAp/PLGA nanofiber membraneMajor: Biomedical EngineeringName: Li ChengpengSupervisor:LecturerLiyan,AbstractThe chemical composition of hydroxyapatite is similar to the main ingredients of bone tissue of human body?. Therefore，hydroxyaptiteHAsattracted?much attention?of?the?researchers. With further research on hydroxyapatite, it was discovered thatthe?biocompatility?of?hydroxyapatite?is?very?well and it can guide the growth of the bone. Hydroxyaptite and bone can reach?osseointegrationwhenitwas embeddedinbones.Therefore,it is widely used for?bonerepair?andreplacementmaterial?of?bone.?PLGA isa biodegradable and non-toxic polymer with wellbiocompatibility. In tissue engineering, PLGA as cell scaffold materials for cell culture is used to provid three dimensional space for cell adhesion. Here, a composite materialas a cell scaffold materialto be usedin tissue engineeringwas preparedvia method of electrostatic spinning using Zn-doped HAP and PLGA as raw materials in this dissertation.In this dissertation, using、 and as starting materials, Zn-doped hydroxyapatite nanorods were prepared via chemical precipitation method. Then fiber membrane was prepared via method of electrostatic spinning using Zn-doped hydroxyapatite