Calcium channel blockers and Vasodilators in Hypertension …在高血压的钙通道阻滞剂与血管扩张剂….pptVIP

Calcium channel blockers and Vasodilators in Hypertension Therapy Dr. Thomas Abraham PHAR 417: Fall 2005 * Proposed role of calcium channels in hypertension Calcium channels divided into L-type, N-type, P-type and Receptor-operated type. Activation of receptors linked to the phosphoinositide system (in vascular smooth muscle) and to the cyclic AMP pathway (cardiac muscle) lead to the opening of plasma membrane calcium channels. Calcium channel blockers ??????? Regulation of SA nodal activity by L-type calcium channels to control heart rate. ? ??????? Regulation of myocardial contrac