支气管哮喘患者血清中-异前列腺素水平研究.docVIP

支气管哮喘患者血清中8-异前列腺素水平研究 ? 598?中国呼吸与危重监护杂志2010年11月第9卷第6期ChinJResoirCfitCareMed.N0vember2010.V01.9.N0.6 支气管哮喘患者血清中8.异前列腺素 水平研究 李永霞陈敏钟红海冰 昆明医学院第二附属医院呼吸内科(云南昆明650101) 【摘要】目的探讨支气管哮喘患者血清中8一异前列腺素(8-iso—PG)水平检测的临床意义. 方法选取2009年2月至8月就诊于昆明医学院第二附属医院呼吸内科的18例哮喘急性发作期患 者为哮喘组,经治疗后达缓解期.选取2009年8月来自昆明医学院第二附属医院的职工体检志愿者 20例为健康对照组.测定所有研究对象血清中8.iso—PG水平及肺功能指标FEV%pred.结果哮 喘患者急性发作期血清中8一iso—PG水平均高于缓解期和健康对照组[(157.46±46.99)pg/mL比 (43.52±13.62)pg/mL和(15.23±1.96)pg/mL,Plt;0.O1],缓解期哮喘患者血清中8一iso—PG水平也 高于健康对照组(Plt;0.01).哮喘患者急性发作期血清中8一iso—PG水平与FEV.%pred呈负相关(r= 一 0.533,Plt;0.05).结论8.iso—PG作为氧化应激反应的标记物参与了哮喘的发病,通过监测其在 哮喘患者血清中的水平可以反映哮喘患者体内氧化应激反应状态,可以作为一种评估哮喘患者病情 严重程度及随访治疗效果的指标. 【关键词】哮喘;8-异前列腺素 Levelsof8?IsoprostaneinSerumofPatientswithBronchialAsthma/2y0一xia,CHENMin, ZHONGttong,HA1Bing.DepartmentofRespiratoryMedicine,SecondAffiliatedHospitalofKunmingMedical Une.Kunming,Yunnan,650101,China CorrespondingAuthor:ZHONGHong,E—mail:liyongxia@hotmail.con 【Abstract】ObjectiveToinvestigatelevelsof8-isoprostaneinserumofpatientswithbronchial asthma.MethodsEighteenpatientsdiagnosedwithacuteexacerbationofasthmawereenrolledasthe experimentalgroupfromDepartmentofRespiratoryMedicinefromFebruary2009toAugust2009.After treatmentallthepatientsreachedremission.TwentyhealthyworkersfromDepartmentofRespiratory MedicinewereenrolledasthecontrolgroupinAugust2009.Thelevelsof8-isoprostaneinserumofall subjectsweremeasured,andtheirFEV1%predwasalsoevaluated.ResultsThelevelsof8-isoprostanein serumweresignificantlyhigherinpatientswithacuteexacerbationofasthmacomparedwiththosein remissionstageandthehealthycontrolgroup[(157.464-46.99)pg/mLUS.(43.524-13.62)pr/mLand (15.234-1.96)pg/mL,Plt;0.O1].Meanwhilethelevelsof8-isoprostaneinserumofpatientswithasthma inremissionstageweresignificantlyhighercomparedwiththehealthycontrolgroup(Plt;0.05).Thelevels of8-isoprostaneinserumwerenegativelycorrelatedwithFEVt%predintheasthmagroup(r=一0.533, Plt;0.05).Conclusions8-isoprostaneasamarkerofoxidativestressresponseinvolvesinthepathogenesis ofasthma.Monitoring8-i