不宁腿综合征的连锁和关联研究-linkage and association study of restless legs syndrome.docxVIP

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不宁腿综合征的连锁和关联研究-linkage and association study of restless legs syndrome.docx

不宁腿综合征的连锁和关联研究-linkage and association study of restless legs syndrome

AbstractRestlesslegssyndrome(RLS)isacommonneurologicaldisordercharacterizedbyanurgetomovethelimbs,andisusuallyaccompaniedbyuncomfortablesensationsthatworsenwithrest,improvewithmovement,andareworseintheeveningornight.Itcanimpairsleepandadverselyaffectshealthandqualityoflife.EpidemiologicalstudiesofRLSrevealedaprevalencerateof5%-24%inCaucasianpopulations,whichismuchhigherthantherateinAsianandAfricanpopulations(0.1%-3.9%),suggestingapossibleroleforethnicfactorsintheoccurrenceofRLS.Furthermore,RLSistwicemorecommoninfemalesthaninmales.RLSisassociatedwithapositivefamilyhistoryin45%to65%ofpatientsand

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