不同时期不同材料引导新生骨的生物力学性能分析-biomechanical analysis of different materials guiding new bone in different periods.docxVIP

Methods: 12 adult Beagle dogs as the object, In its bilateral femoral condyle prepared 3 cylindrical defects,3mm diameter,10mm height. Do GBR surgery, implant bio-oss(group B),β-TCP(group C) and autogenous bone(group Z),cover the bio-membrane. Sacrifice 6 dogs in each three and six months after surgery, preparation specimens. Some do CBCT scanning ,observe the situations of bone formation. Some do compression test, detect the ability of compression of guided bone. Some do implant surgery, detect immediate torque. And some do push-out test, detect binding ability between new bone and natural bone. Results: We have successfully established animal models. CT displayed that every group have osteogenesis, and 6-mouth groups are better than 3-mouth groups. Compression test:6-mouth groups are better than 3-mouth groups, group Zgroup Bgroup C in 3-mouth groups, group Zgroup C and group Bgroup C in 6-mouth groups. Immediate torque test: group Zgroup C and group Bgroup C in either 3-mouth groups or 6-mouth groups, only the average torque of group C in 3-mouth groups is lower than 30N/cm,others are all higher than 30N/cm. Push-out test:6-mouth groups are better than 3-mouth groups, and group Bgroup C.Results: Compared the new bones guided by bio-oss and β-TCP, found that bio-oss was better than β-TCP in compressive strength, could provide better primary stability in plant, and had superiority in ability of combined with natural bone.Key Words: GBR/ bio-oss/ β-tricalcium phosphate/ CBCT/ Biomechanics前言目前临床上种植义齿已成为缺失牙修复的首选方法之一，因为其具有 不损伤邻近天然牙、外形与天然牙相近无异物感、咀嚼功能恢复较高以及 使用寿命较长（数十年）等优点，被广大医生及患者所接受[1]。影响种植 义齿成功的首要因素即受植区骨条件，骨高度或宽度的不足均无法给种植 义齿提供足够的支持，而骨质量的不同会影响种植手术后的远期成功率。 有学者[2]对不同骨密度条件中的种植牙骨结合稳定系数(ISQ)进行了研究， 其中对失败率进行分析的结果显示，一级骨的失败率最高，四级骨次之， 二级骨和三级骨最低。然而临床上大多数缺失牙的种植骨条件都不理想， 存在骨量不足或骨质缺陷的问题，其原因很多，如：拔牙损伤、活动假牙 的长期佩戴、炎症、外伤、肿瘤等。为满足种植手术的成功，常需进行骨 增量，方法包括骨移植、骨引导、牵张成骨等。自体骨移植因需开辟第二 手术区，存在取骨区骨再生等问题不能被大多数患者接受；牵张成骨治疗 周期较长，可能给患者带来较持续的痛苦，也无法作为常规使用的方法。 因此人们积极探索寻求各种骨组织替代材料来弥补以上不足。近年来引导骨再生技术（GBR）应