Fluorescence Microscopy Study荧光显微镜的的研究.pptVIP

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2018-06-28 发布于福建
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Fluorescence Microscopy Study荧光显微镜的的研究.ppt

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Fluorescence Microscopy Study荧光显微镜的的研究

Fluorescence Microscopy Study (pilot study) Study design: Individual pilot study. One forearm of a healthy 63-year old male volunteer received application of DermatoPoietin? and another forearm received Placebo once-a-day for 28 days. Fluorescence microscopy measurements were performed at baseline (day 0), day 7, 14, and 28. Study performance: Dr. Leonard Khiroug, Neurotar Ltd., Helsinki, Finland Purpose of Study: To assess the effect of DermatoPoietin? on collagen and elastin deposition in skin by fluorescence microscopy using two-photon laser technique. Neurotar Ltd , Helsinki Finland United Technologies UT AG? Fluorescence Microscopy Images Day 0 and Day 28 Neurotar Ltd , Helsinki, Finland United Technologies UT AG? Red fibers – Collagen; Green fibers - Elastin Day 0 Day 0 Day 28 Day 28 DermatoPoietin? Replenishes Collagen / Elastin in Skin Before (day 0) After (day 28) + 80% Red – Collagen; Green - Elastin Red – Collagen; Green - Elastin Neurotar Ltd , Helsinki Finland United Technologies UT AG? DermatoPoietin? (Day 0) Neurotar Ltd , Helsinki, Finland DermatoPoietin? (Day 28) Neurotar Ltd , Helsinki , Finland Time Course of DermatoPoietin? Effect on Collagen Day 0 Day 7 Day 14 Day 28 The effect on collagen replenishment in aged skin is observed as early as 7 days after start of treatment with DermatoPoietin? and reaches a maximum after about 2 weeks. Neurotar Ltd , Helsinki, Finland United Technologies UT AG? Red – DermatoPoietin? ; Blue – Placebo Fluorescence Microscopy: Conclusions Application of DermatoPoietin? for 28 days increases the amount of collagen in aged skin by 83% as compared to Placebo. Neurotar Ltd , Helsinki Finland United Technologies UT AG? The effect is fast. Changes in skin collagen are observed as early as 7 days after start of treatment. The increase of collagen is accompanied by a coordinated increase in elastin fibers. Collagen and elastin fibers form a well-organized network. Fluorescence microscopy provides an ex