Stem Cells and Lineages Mechanisms of Lung …：干细胞和肺细胞的机制….pptVIP

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2018-06-29 发布于浙江
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Stem Cells and Lineages Mechanisms of Lung …：干细胞和肺细胞的机制….ppt

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Stem Cells and Lineages Mechanisms of Lung …：干细胞和肺细胞的机制…

* * * * * * * * * * * * * * * * * Saccular phase (E17.5-P5)Control of epithelial differentiation II This leaves out NFI, GR, Gata6, SP3, Sox11, HIF2A, TGF?3 and other TFs and GFs that affect maturation. Nfib Alveolarization (P5-P28) Terminal differentiation of type I cells Further reduction in mesenchyme Increased surfactant expression in type II cells Expansion of saccules into alveoli with septation Just so you dont think its too simple Just so you dont think its too simple Just so you dont think its too simple Just so you dont think its too simple Things we left outVasculatureRepair of damageLung Stem CellsLung diseasesImmune responses Review of mouse lung development Cordoso, Dev. Dyn. 219:121 (2000) Neonatology: SE Wert 5th edition 1999. Overview of mouse lung development Pseudoglandular Canalicular Saccular Alveolar Review of mouse lung development Neonatology: SE Wert 5th edition 1999. Cordoso, Dev. Dyn. 219:121 (2000) Pseudoglandular Canalicular Saccular Alveolar Overview of mouse lung development How to build an organ Reciprocal Epithelial-Mesenchymal interactions mediated by growth factor- and cell contact-regulated transcriptional networks. These interactions both constitute a program for growth, morphogenesis and differentiation and then help establish the quazi-stable epigenetic states that characterize each differentiated cell. Many organs follow this strategy with the addition of other processes such as cell-recruitment, Epithelial-Mesenchymal transitions (EMT) and Mesenchymal-Epithelial transitions (MET). * * * * * * * * * * * * * * * * * * * * * * * Stem Cells and Lineages: Mechanisms of Lung Development Overview of stages of lung development Epitheial-Mesenchymal interactions Budding Branching morphogenesis Sacularization and Alveolarization (Maturation) Genes and growth factors that control these processes Focus on how these molecules were shown to play a role in the processes Lungs did not develop from gills, they are a complete