Materials for fibrous proteins and connective tissue：纤维蛋白和结缔组织的材料.pptVIP

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Materials for fibrous proteins and connective tissue：纤维蛋白和结缔组织的材料.ppt

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Materials for fibrous proteins and connective tissue：纤维蛋白和结缔组织的材料

In support of chapter 8, pg. 6 From Beighton P. Inherited Disorders of the Skeleton, Edinburgh ; New York : Churchill Livingstone, 1988. In support of chapter 8, pg. 10. From Morris CA, and Mervis CB. Williams Syndrome and related disorders. Ann. Rev. Genomics Hum. Genet. 1:461-484. (2000). In support of chapter 8, pg. 10 From Li B, and Daggett V. Molecular basis for the extensibility of elastin. J. Muscle Res. and Cell Motility 23: 561-573 (2003). In support of chapter 8, pg.1 alpha keratins. In support of Chapter 8, pg. 6. Summary of collagen biosynthetic steps described in chapter 8, starting on pg. 6 Supporting chapter 8, pg. 9 Supporting Chapter 8, pg. 9. Supporting Chapter 8, pg. 9 In support of chapter 8, pg. 12. In support of chapter 8, pg. 13. From Luo, B-H, Carman, C.V., and Springer, T.A. Structural basis of integrin regulation and signaling. Annual Review of Immunology 25: 619-647 (2007) From chapter 8, pg. 3 From chapter 8, pg. 4; see also chapter 5. From chapter 8, pg 5. Information from Prockop and Kirrikko, Ann. Rev. Biochem. 64: 403-34 (1995) Chapter 8, pg. 7 Examples of collagen nomenclature: An individual polypeptide: a1(I) procollagen Assembled triple helix with propeptides still on: Type I procollagen Triple helix after propeptide removal: Type I tropocollagen Assembled into 50 nm fiber: Collagen microfibril A third lysine (from a third tropocollagen) can add to make pyridinoline. Crosslinks involving hydroxylysine are more stable than those involving lysine. There is also a crosslink involving histidine. Steps in collagen biosynthesis: Translation on rough ER and entry into ER. Hydroxylation in the ER. Triple helix assembly. Glycosylation, transport to Golgi, further glycosylation. Secretion. Removal of propeptides. Assembly into fibrils. Crosslinking. + (or else degrade) vitamin C + HOlys HOpro + + Elastin: Where: elastic connective tissues. Cellular location: extracellular matrix Function: add elasticity to connective tissue Structure: beta