支原体肺炎患儿血清白介素6、肿瘤坏死因子―α、C―反蛋白水平及临床意义.docVIP

支原体肺炎患儿血清白介素6、肿瘤坏死因子―α、C―反应蛋白水平及临床意义 　　[摘要] 目的 探讨肺炎支原体肺炎（MPP）患儿血清白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和C-反应蛋白（CRP）的水平变化及临床意义。 方法 选择2013年1～12月延安大学附属医院儿科收治的MPP住院患儿60例作为病例组，并根据其治疗转归情况分为急性期及恢复期，选择同期门诊健康体检儿童55例作为对照组。测定各组患儿不同时期血清IL-6、TNF-α和CRP水平，并进行比较。采用Pearson相关性分析MPP患儿急性期血清CRP、IL-6、TNF-α水平的相关性。 结果 MPP患儿急性期血清IL-6[（56.21±19.27）ng/L]、TNF-α[（21.43±5.67）ng/L]和CRP水平[（28.35±7.79）mg/L]均高于同组恢复期[（15.52±5.91）ng/L、（9.31±4.93）ng/L、（6.04±1.11）mg/L]和对照组[（13.97±5.17）ng/L、（8.79±4.87）ng/L、（5.87±0.84）mg/L]，差异均有统计学意义（P 0.05）。相关性分析显示，病例组急性期血清CRP水平与IL-6、TNF-α呈正相关（r = 0.5596、0.5522，P 中国论文网 /6/viewhtm　　[关键词] 支原体肺炎；白介素-6；肿瘤坏死因子-α；C-反应蛋白 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1673-7210（2015）09（c）-0106-03 　　[Abstract] Objective To investigate the levels of serum IL-6， TNF-α and CRP in children with mycoplasma pneumoniae pneumonia （MPP） and its clinical significance. Methods From January to December 2013， in Department of Paediatrics， the Affiliated Hospital of Yanan University， 60 children with MPP were selected as case group. According to the treatment and prognosis of disease， children were divided into the acute stage and recovery stage. At the same time， 55 healthy children with physical examination in Outpatient Clinic were selected as control group. The serum levels of IL-6， TNF-α and CRP in different groups and stages were detected and compared. Pearson test was applied to analyzed the correlation among levels of CRP， IL-6 and TNF-α. Results The serum levels of IL-6 [（56.21±19.27） ng/L]， TNF-α [（21.43±5.67） ng/L] and CRP [（28.35±7.79） mg/L] of children with MPP in acute stage were significantly increased than those in recovery stage [（15.52±5.91） ng/L， （9.31±4.93） ng/L， （6.04±1.11） mg/L] and control group [（13.97±5.17） ng/L， （8.79±4.87） ng/L， （5.87±0.84） mg/L]， the differences were statistically significant （P 0.05）. Correlation analysis showed that serum level of CRP had positive correlation with IL-6 and TNF-α of children with MPP in acute stage （r = 0.5596， 0.5522， P 　　肺炎支原体肺炎（MPP）是由肺炎支