探讨新生儿葡萄糖―6―磷酸脱氢酶缺乏症患儿生后早期血清总胆素水平变化.docVIP

探讨新生儿葡萄糖―6―磷酸脱氢酶缺乏症患儿生后早期血清总胆红素水平变化 　　【摘要】 目的：分析研?新生儿葡萄糖-6-磷酸脱氢酶（G-6-PD）缺乏症患儿生后早期血清总胆红素（TSB）指数状况。方法：用随机抽签方式，从2015年2月-2016年7月将本院产科出生的足月儿90例纳入到讨论中，90例研讨对象均接受脐带血G-6-PD酶活性定量检查，按照检查结果分正常组（40例）和缺乏组（50例），统计记录新生儿生后各阶段TSB含量、高胆红素血症发生率，分析高胆红素血症发生率、TSB上升速率，并进行比较。结果：新生儿出生3 h内以及出生后第1、2、3天，缺乏组的TSB指数均高于正常组，差异均有统计学意义（P中国论文网 /6/viewhtm　　【关键词】 胆红素； 血清； 新生儿葡萄糖-6-磷酸脱氢酶缺乏症； 出生后 　　Investigation of Changes of Serum Total Bilirubin Levels in Neonates Glucose-6-phosphate Dehydrogenase Deficiency at Early Stage after Birth/GUO Hong-chuang，XIAO Qi-zhi，HUANG Hui-wen.//Medical Innovation of China，2017，14（30）：030-032 　　【Abstract】 Objective：To analyze and discuss the status of serum total bilirubin index in neonates with glucose-6-phosphate dehydrogenase deficiency at early stage after birth.Method：90 full-term infants and who born in our hospital department of obstetrics from February 2015 to July 2016 were included in the discussion by the random ballot method，and 90 discussion objects were received the quantitative examination of G-6-PD enzyme activity in cord blood，and were divided into the normal group （40 cases） and the lack group （50 cases）according to the results of the examination.The TSB content，hyperbilirubinemia rate and the rate of hyperbilirubinemia and the rising rate of TSB in neonates were recorded and compared.Result：The neonatal birth rate was 3 h and the first，second，third day after birth，the TSB indices in the absence group were higher than those in the normal group，the differences were statistically significant（P 　　【Key words】 Bilirubin； Serum； Neonatal glucose-6-phosphate dehydrogenase deficiency； After birth 　　First-author’s address：The Maternal and Child Health Care Hospital of Zhuhai City，Zhuhai 519000，China 　　doi：10.3969/j.issn.1674-4985.2017.30.009 　　本院新生?焊叩ê焖匮?症多种因素中，较为常见的为新生儿葡萄糖-6-磷酸脱氢酶缺乏症[1-2]，且在胆红素脑病病因中占据首位。此研究采用分组研讨90例新生儿的方式进行分析，现报告如下。 　　1 资料与方法 　　1.1 一般资料 用随机抽签方式，从2015年 　　2月-2016年7月将本院产科出生的足月儿90例纳入到讨论中，入选标准：均为足月儿、出生体重正常[3-4]；排除标准：存在可能引发高胆红素血症的其他因素，如Rh和