IVFICSI术后用黄体酮阴道缓释凝胶作黄体支持临床情况分析.docVIP

IVFICSI术后用黄体酮阴道缓释凝胶作黄体支持临床情况分析 　　【摘要】目的探讨阴道放置黄体酮阴道缓释凝胶(商品名:雪诺同8%)在体外受精(IVF)和卵细胞浆内单精子注射(ICSI)术后黄体支持的临床疗效。方法回顾性分析了进行体外受精-胚胎移植(IVF-ET) 138个新鲜周期的患者临床资料, 按不同黄体支持方法分两组：黄体酮肌内注射组(A组)60例, 阴道放置雪诺同8% (B组)78例。观察两组的着床率、临床妊娠率、早期流产率以及药物不良反应发生率。结果138个新鲜周期中, 术后随访期间妊娠共81例, 总临床妊娠率为58.7%(81/138), B组的临床妊娠率高于A组的临床妊娠率, 差异有统计学意义(P0.05)。结论阴道放置雪诺酮8%在IVF-ET术后进行黄体支持是有效的黄体支持方案, 可提高临床妊娠率, 且使用简便, 可避免患者由于注射黄体酮产生的不良反应。 　　【关键词】体外受精-胚胎移植(IVF-ET)；雪诺同8%；黄体支持 　　 　　Analysis of clinical information of progesterone sustained-released vaginal gel as luteal phase support in in-vitro fertilization and intracytoplamsic sperm injection cycles XU Li-hua, CHE Xiao-qun, SONG Li-jun, et al. Center of Reproductive Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China 　　【Abstract】Objective#8195;To investigate the therapeutic effect of progesterone sustained-released vaginal gel( Crinone8%) as luteal phase support in in-vitro fertilization(IVF) and intracytoplamsic sperm injection( ICSI) cycles. Methods#8195;Clinical data of 138 cycles were analyzed retrospectively. They were divided into two groups according different luteal support randomly. Group A:60 cases, with progesterone as luteal support. Group B:78 cases, with Crinone 8% Gel as luteal support.Implantation rate, clinical pregnancy rate, miscarriage rate and adverse drug reaction rate were observed. Results#8195;All of the 138 cases, 81 became pregnant within the follow up. The total clinical pregnancy rates were 58.7%(81/138). The pregnancy rates of group B were significantly higher than group A. The adverse drug reaction rate of group B was lower than group A, its’differences had statistic significance(P0.05). Conclusion#8195;It is an effective program with vaginal administration of Crinone 8% gel as luteal support in in- vitro fertilization-embryo transfert. It can improve clinical pregnancy rate. Furthermore, it can avoid adverse drug reaction from the injection of progesterone and use conveniently. 　　【Key words】In-vitr