【持续性肾脏替代治疗CRRT英文ppt课件】Prevention and Treatment of Acute Renal Failure in Sepsis.pptVIP

Prevention and Treatment of Acute Renal Failure in SepsisAN S. DE VRIESEJ Am Soc Nephrol 14: 792–805, 2003;Introduction;Prevention and Treatment of Acute Renal Failure in Sepsis;Treatment with Fluids, Vasopressors, and Diuretics;I. Volume Expansion;I. Volume Expansion;II. Vasopressors;Norepinephrine;Vasopressin;II. Vasopressors;III. Low-Dose Dopamine;III. Low-Dose Dopamine;IV. Diuretics;;Specific Pharmacologic Treatment;Anti-TNF-? Therapy;Inhibition of Platelet-Activating Factor;Inhibition of Nitric Oxide Synthase ;Endothelin Antagonism;Inhibitors of Arachidonic Acid Metabolism;Natriuretic Peptides;Inhibition of Leukocyte Adhesion;Inhibitors of Coagulation -Rationale;Inhibitors of Coagulation -Rationale;Activated Protein C;Proposed Actions of Activated Protein C in Modulating the Systemic Inflammatory, Procoagulant, and Fibrinolytic Host Responses to Infection--N Engl J Med, Vol. 344, No. 10·March 8, 2001 TAFI: thrombin-activatable fibrinolysis inhibitor ; PAI-1: plasminogen-activator inhibitor 1 ;Activated Protein C;Kaplan–Meier Estimates of Survival among 850 Patients with Severe Sepsis in the Drotrecogin Alfa Activated Group and 840 Patients with Severe Sepsis in the Placebo Group.;Inhibitors of Coagulation -Conclusion;Growth Factors ;Potential Treatments of ARF -Conclusion;Dialytic Treatment;Dialytic Treatment;Dialytic Treatment;Extracorporeal Inflammatory Mediator Removal;The 5 of TNF-α, IL-1β, IL-6 that was removed after the start of CVVH in 15 pts with septic shock ARF.(change filter at 12hrs);Conclusion;The END