毛酸浆浆果的化学成分分析-analysis of chemical constituents of physalis alkekengi.docxVIP

Stud Studies on Chemical Constituents from Berries of Physalis pubescens L. Abstract III III IV IV Studies on Chemical Constituents from Berries of Physalis pubescens L. Abstract Physalis pubeacens L. has long been a minor fruit of China and has also been grown in America. The fruit of the Physalis Genus was also extensively used as herb medicine, and had the effects of detoxification and anti-inflammation in traditional Chinese medicine. the extract of fruits of the Physalis Genus had been reported to have potent antioxidant, anti-inflammatory, and cytotoxic activities. Previous studies on constituents from the Physalis genus led to the isolation of different compounds such as triterpenoids, flavones, alkaloids and steroids. During the course of our investigation for bioactive agents from the EtOH extract of calyxs of Physalis pubeacens L., 30 compounds were obtained by using silica gel column chromatography, Sephadex LH-20 chromatography, MPLC, and Semi-HPLC, and structures of 26 compounds were elucidated through spectroscopic analysis (NMR, MS and IR ). Their structures were identified to be 3, 7, 3-trimethylquercetin (SG-1), kaempferol (SG-2), chrysoeriol (SG-3), quercetin-3-O-β-D-glucopyranoside (SG-4), arjunolic acid (SG-5), pulsatilla saponin A (SG-6), pulsatilla saponin D (SG-7), blumenolA (SG-8), caffeic acid (SG-9), 1-O-caffeoyl-β-D-glucopyranoside (SG-10), syringic acid β-D-glucopyranosyl ester (SG-11),5-O-caffeoyl quinic acid butyl ester (SG-12), 1-p-coumaroyl-β-D-glucopyranoside(SG-13), Calceolarioside A (SG-14),4-hydroxyl-3-methoxyl-benzoicacid(SG-15),1-O-p-feruloyl-β-D-glucopyranoside (SG-16), N-trans-p- hydroxyphenethylferolamine (SG-17), neo-olivil (SG-18), medioresinol (SG-19), pinoresinol (SG-20), sucrose (SG-21), uridine (SG-22), adenosine (SG-23), northrachelogenin (SG-24), β-sitosterol (SG-25), daucosterol (SG-26)。Among them, SG-5~SG-8,SG-10,SG-11,SG-13~SG-24 were isolated from this genu