and FAP are both associated with familial colon HNPCC和FAP都与家族性结肠癌相关ppt课件.pptVIP

HNPCC and FAP are both associated with familial colon cancer but differ in many aspects. Describe the similarities and differences between these conditions. How does MYH polyposis differ from both?;Essay plan;Colorectal cancer;Diagnosis of hereditary colorectal cancer;Cancer predisposition;Inheritance;Gene/s involved;Mismatch repair genes (MMR)e.g. MLH1, MSH2, MSH6, PMS2;Tumour suppressor genes e.g. APC;Microsatellite instability (MSI) vs chromosomal instability (CIN);Types of mutation;Testing methods;Surveillance;MYH polyposis (differences between this and HNPCC FAP);MYH polyposis: Base