原发性骨质疏松症ppt课件.pptxVIP

骨质疏松症北京协和医院 内分泌科夏维波weiboxia@背影－她们的。。。主要内容骨质疏松症：概念和分类流行病学特征发病机制临床表现诊断和危险因素防治主要内容骨质疏松症：概念和分类流行病学特征发病机制临床表现诊断和危险因素防治骨质疏松症一种以骨量减少，骨组织微结构破坏，骨骼脆性增加和易发生骨折的全身性疾病。（1994） 一种代谢性骨病。其特征为骨强度下降导致骨折危险性增加。骨强度取决于骨密度与骨质量。（2001） 正常骨 骨质疏松症The NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. JAMA 285:785-795, 2001Normal BoneOsteoporotic BoneDefinition of Osteoporosis? A skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture.? Bone strength reflects the integration of two main features: bone density and bone quality.Images courtesy of Ralph Müller正常骨骼疏松骨骼骨骼的结构和质量正常材料和结构材料不足正常材料和异常结构骨质疏松症的分型原发性骨质疏松症绝经后骨质疏松症 （I型）老年性骨质疏松症 （II型）特发性骨质疏松症继发性骨质疏松症主要内容骨质疏松症：概念和分类流行病学特征发病机制临床表现诊断和危险因素防治世界第六位的常见病--骨质疏松症骨质疏松症患病率：IOF统计：全球2亿骨质疏松症患者，其中80%为绝经后女性美国、欧洲和日本共计7500万患者中国骨质疏松症患者约7000-8000万1.National Osteoporosis Foundation Fast Facts.不同性别骨质疏松症患病率的差异目前，美国有1，000万骨质疏松症患者，其中80%为女性，20%为男性1截至2002年2，中国骨质疏松症患者达8.826千万，男女比例为1：61./osteoporosis/diseasefacts.htm#gender2. Wu XP, Liao EY, Luo XH, et al. Age-related variation in quantitative ultrasound at the tibia and prevalence of osteoporosis in native Chinese women. Br J Radiol 2003;76:604-10 Changes in population over the next 40 years will have massive impact on healthcare and general welfareConsiderations Care of the elderly Pensions Immigration Healthcare costs Working age increased Reduced child numbers中国绝经后妇女骨质疏松症的患病率SpineFemoral Neck7060.26053.853.35042.3% of Women4028.925.4302011.1101.300040-49 50-59 60-69 70-79 80-89 40-49 50-59 60-69 70-79 80-89Age RangeAge Range1Based upon Hologic cut-off values. Spine = 0.717 g/cm2, femoral neck = 0.493 g/cm2Woo et al. Osteopor Int (2001);12:289-293Prevalence of osteoporosis in the mid-aged and elderly in China5593 subjects from cities in 5 areas of China by the stratified-multi-steps cluster sampling methodLI NH, et al, Chinese Medical Journal 2002; 115 5 :773-775Prevalence of age-related osteoporosis at different sites in