曲彦耐药时代的经验性抗感染治疗ppt课件.pptVIP

耐药时代的经验性抗感染治疗 ;;BAD BUG,NO DRUG, NO ESKAPE;*;GNB依然是乱世魔王;*;Importance of Adequate and Appropriate Antimicrobial Treatment;选择哪种抗菌药物(which antibiotic?) 感染部位的常见病原学(possible pathogens on site of infection) 选择能够覆盖病原体的抗感染药物(antibiotics requirement) -抗菌谱/组织穿透性/耐药性/安全性/费用 考虑药代动力学/药效动力学(PK/PD) 考虑病人生理和病理生理状态( physiologic and pathophysiology) 高龄/儿童/孕妇/哺乳(advanced age/children/pregnant women/breast feeding) 肾功能不全/肝功能不全/肝肾功能联合不全(renal/heptic dysfunction/combined) 其它因素(other considerations) 杀菌和抑菌/单药和联合/静脉和口服/疗程 (cidal vs static/ mono vs combination/ IV vs P