肾部分切除术后术肾功能影响因素研究-study on influencing factors of renal function after partial nephrectomy.docxVIP
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肾部分切除术后术肾功能影响因素研究-study on influencing factors of renal function after partial nephrectomy
laparoscopicsurroundings.ObjectiveToinvestigatethemainfactorspredictingfunctionaloutcomesofoperatedkindeyafterpartialnephrectomy(PN).MethodsFromOctober2007toJuly2009,37patientsunderwentopenpartialnephrectomy.Therewere3patientsofbilateralrenalcancers.Glomerularfiltrationrate(GFR)oftherenalunitswithtumorfrom99mTc-Diethylenetetraminepentaaceticacid(99mTc-DTPA)renalscanwasmeasuredpreoperativelyand3monthspostoperatively.PNwasperformedbyrenalarteryclampingaloneinallpatients.Patient,tumorandperioperativecharacteristicswithrespecttochangesinGFRofoperatedkidneyhadbeenanalyzed.StatisticalanalysiswasperformedusingtheStudentttestandmultivariatelinearregressionanalysis.ResultsOperationtimewas80~195min,mean(122.51±25.86)min.Meanofclampingtimewas(24.51±8.05)min.Meanoftumorsizeswas(3.62±0.76)cm.MeanpreoperativeGFRandpostoperativeGFRafter3monthswere(47.19±6.85)ml/minand(30.4±8.87)ml/min,respectively.ReductionandpercentreductioninGFRwere(16.79±6.35)ml/minand34%,respectively.Atfollowupof3~21months,therewerenorecurrenceormetastasis.Allpatientswerealive.Onmultivariateanalysis,Age,clampingtimeofrenalarteryandpreoperativeGFRofoperatedkindeyweresignificantwithpvalue0.004,0.000,0.000,respectively.ConclusionsAge,clampingtimeandpreoperativeGFRofoperatedkindeywerethemainfactersinfluencingrenalfunctionafterPN.KEYWORDS:carcinoma,renalcell/kidneyfunctiontests/glomerularfiltrationrate/nephrectomy中英文缩略词表英文缩写英文全称中文全称RCCRenalcellcarcinoma肾细胞癌RNRadicalnephrectomy根治性肾切除术PNPartialnephrectomy肾部分切除术GFRGlomerularfiltrationrate肾小球滤过率ScrSerumcreatinine血清肌酐LPNLaparoscopicpartialnephrectomy腹腔镜肾部分切除术Ccr99mTc-DTPAEndogenouscreatinineclearancerate99mTc-Diethylenetetraminepentaaceticacid内生肌酐清除率99m锝-二乙三胺五乙酸ECTEmissioncomputedtomography同位素发射计算机断层显像学位论文独创性声明本人所呈交的论文是我个人在导师指导下进行的研究工作及取得的研究成果。据我所知,除了文中特别加以标注和致谢的地方外,论文中不包含其他人已经发表或撰写过的研究成果。与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确说明并表示谢意。学位论文作者签名:日期:学位论文使用授权声明本人完全了解安徽医科大学有关保留、使用学位论文的规定:学校有权保留学位论文并向国家主管部门或其指定机构送交论文的电子版和纸质版,有权允许论文进入学校图书馆被查阅,有权将学位论文的内容编入有关数据库进行检索,有权将学位论文的标题和摘要汇编出版。愿意将
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