Zika病毒非结构蛋白3和5的结构特点和其个人域解决方案以及见解NS3抑制：（Structural features of Zika virus non-structural proteins 3 and -5 and its individual domains in solution as well as insights into NS3 inhibition）.pdfVIP

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Zika病毒非结构蛋白3和5的结构特点和其个人域解决方案以及见解NS3抑制：（Structural features of Zika virus non-structural proteins 3 and -5 and its individual domains in solution as well as insights into NS3 inhibition）.pdf

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Antiviral Research 141 (2017) 73e90 Contents lists available at ScienceDirect Antiviral Research journal homepage: /l ocate/antiviral Structural features of Zika virus non-structural proteins 3 and -5 and its individual domains in solution as well as insights into NS3 inhibition 1 1 Wuan Geok Saw , Ankita Pan , Malathy Sony Subramanian Manimekalai, * Gerhard Grüber Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, 637551, Singapore a r t i c l e i n f o a b s t r a c t Article history: Zika virus (ZIKV) has emerged as a pathogen of major health concern. The virus relies on its non- Received 14 November 2016 structural protein 5 (NS5) including a methyl-transferase (MTase) and a RNA-dependent RNA poly- Received in revised form merase (RdRp) for capping and synthesis of the viral RNA and the nonstructural protein 3 (NS3) with its 10 February 2017 protease and helicase domain for polyprotein possessing, unwinding dsRNA proceeding replication, and Accepted 11 February 2017 NTPase/RTPase activities. In this study we present for the ﬁrst time insights into the overall structure of Available online 12 February 2017 the entire French Polynesia ZIKV NS3 in solution. The protein is elongated and ﬂexible in solution. So- lu