红斑狼疮 SLEEnglishpre 中山大学 内科学ppt课件.pptVIP

Systemic Lupus Erythematosus;Background:;Epidemiology and Etiology Pathophysiology Clinical features Treatment ;Epidemiology and Etiology;Frequency;Sex;Age;Causes;At least 10 different gene loci are known to increase the risk for SLE. A genetic predisposition is supported by the 10-fold increase in concordance among monozygotic twins versus dizygotic twins. Studies of the human leukocyte antigens (HLA) reveal that HLA-DR2 and HLA-DR3 occur more often in people with SLE than in the general population.;The presence of the null complement alleles and congenital deficiencies of complement (espec