management of Ischaemic heart disease stroke 缺血性心脏病药物治疗中风ppt课件.pptVIP

Side effects Peripheral vasodilation - flushing, headache, ankle oedema Cardiac effects - AV block, heart failure Constipation Short-acting dihydropyridines a/w ? mortality and MI Potassium channel activators Potassium channel activators - nicorandil Activates K ATP channel NO donor effects Arterial and venodilator S/E Flushing, dizziness, headache Usually 3rd or 4th line agent Selective pacemaker If current inhibitor Ivabradine (Procolalan) reduces spontaneous beating rate of the sinus node by slowing the diastolic depolarization slope of the action potential selective and prolon