失眠患者神经损伤标志物水平变化研究.docVIP

失眠患者神经损伤标志物水平变化研究 　　[摘 要] 目的：?z测失眠患者神经损伤标志物水平变化，为失眠发病机制的探索提供新的思路。方法：104例失眠患者，按照其治疗情况分为初诊组（n=66）、复诊组（n=38），并选取同期30名健康体检者纳入对照组。检测三组受试者血清神经丝重链（NfH）、神经元特异性烯醇化酶（NSE）、S100钙结合蛋白B（S100B）水平，并分析上述神经损伤标志物与受试者多导睡眠图（PSG）参数的相关性。结果：初诊组NfH高于复诊组，NSE高于复诊组合对照组，初诊组、复诊组血清NfH、S100B均高于对照组，差异有统计学意义（P0.05）。初诊组睡眠潜伏期高于复诊组，其睡眠效率低于复诊组、对照组，初诊组、复诊组睡眠潜伏期高于对照组，差异有统计学意义（P0.05）。相关性分析显示NfH与睡眠潜伏期呈正相关，NSE与睡眠效率呈负正相关（P0.05）。结论：失眠患者血清NfH、NSE、S100B均显著升高，经治疗后，患者血清NfH、NSE明显降低且PSG参数有所改善，神经损伤标志物与患者病情变化具有密切关联。 　　[关键词] 失眠；神经丝重链；神经元特异性烯醇化酶；S100钙结合蛋白B 　　中图分类号：R741.04 文献标识码：A 文章编号：2095-5200（2017）05-001-03 　　DOI：10.11876/mimt201705001 　　Study on the level of nerve injury markers in patients with insomnia WANG Anna， TU Jiexia， WANG Hongzhou. （Department of Neurology，Sichuan Mianyang 404 Hospital， Mianyang 621000， china） 　　[Abstract] Objective： The objective of this study was to detect the changes of markers of nerve injury in patients with insomnia， and to provide new ideas for exploring the pathogenesis of insomnia. Methods： A total sample of 104 insomniacs were divided into first visit group （n=66） and return visit group （n=38） based on their treatments， and 30 healthy individuals were selected as the control group. The levels of serum neurofilament heavy-chain （NfH）， neuron specific enolase （NSE） and S100 calcium binding protein B （S100B） by three groups of subjects were detected. The correlation between the above markers of nerve injury and the parameters of subjects’ polysomnography （PSG） was analyzed. Results： NfH of first visit group was higher than that of return visit group， NSE of first visit group was higher than that of return visit group and that of control group， NfH and S100B of first visit group and return visit group were both higher than those of control group， and the differences were statistically significant （P0.05）. The sleep latency of first visit group was higher than that of return visit group， the sleep efficiency of first visit group was lower than that of return visit group and contr