进行性多灶性白质脑病ppt课件_1.pptVIP

Progressive Multifocal Leukoencephalopathy;;;JC病毒;PML病因学;;;中枢神经系统 JC 病毒感染;经典型PML;;Enlarged nuclei containing viral inclusions Hematoxylin and eosin;Classic PML: demyelinating lesion of the white matter (arrow) surrounded by multiple JCV-infected glial cells (arrowheads).;;;;;; A 40 yo man with HIV infection, who presented with progressive onset of word finding difficulties and right hemiparesis followed by seizure, 4 days after starting cART. PCR was positive for JCV in the CSF peripheral CD4 count was 468 cells/ul. MRI performed at another hospital reported a 3 cm focus of abnormal inc