脂肪组织内分泌与肥胖症ppt课件.pptVIP

脂肪组织的内分泌功能;脂肪组织;Adipokines;Adipocyte-derived factors exerts on both the central nervous system and the periphery; 几种重要的脂肪细胞因子及其作用;;Ob mouse: obesity;瘦素（leptin)的发现;Leptin--瘦素;;瘦素;Leptin was involved in control of appetite and growth, puberty, digestion and immunological processes. Leptin can also have negative consequences, such as, for example, enhancing the spread of tumorous growths. The development of this mutated “antagonistic leptin” could have significant consequences on halting undesirable leptin effects.;Leptin receptor;（一）具有酪氨酸蛋白激酶活性的受体;;属造血因子类受体 超家族 ;Leptin-signaling pathway;;Leptin function 1—control food intake and body weight;Leptin function 2—regulate the onset of puberty and reproduction;;;;;脂联素，adiponectin;3 D structure of adiponectin (trimer);Cryoelectron micrographs adiponectin;Post-translational modifications resulted in oligomerization of fAd into trimers (LMW), hexamers (MMW) and oligomers (HMW); protease-mediated cleavage of fAd to produce the N-terminal fragment and the C-terminal globular domain. Binding of adiponectin forms to membrane receptors (e.g. gAd has high affinity only for AdipoR1). ;Adiponectin signaling;Adiponectin-insulin signaling cross-talk;Adiponectin function 1 —decrease the body weight;调节糖代谢: 降低血糖，增加机体对胰岛素的敏感性，抑制胰岛?细胞凋亡； 调节脂代谢：促进脂肪酸的氧化，增加游离脂肪酸(free fatty acide，FFA)的清除，从而减少了血清甘油三酯和FFA的浓度；;Adiponectin function 3 —anti-inflammation and anti-artherosclerosis;;抵抗素 resistin;抵抗素的发现;;Resistin function 1 —inhibit the differentiation of adipocytes;Resistin function 2 —regulate the insulin induced glucose transport;;Resistin function 3 —influence on the immune system;;Resistin function 4 —influence on the vascular system;其他脂肪细胞因子-IL6;;脂肪内分泌与肥胖症及其相关疾病;肥胖症;肥胖症;肥胖症;肥胖症;肥胖症;肥胖与神经调节;饱感的产生和进食的终止;;机体脂肪储存信号与进食调节;;与进食有关的中枢;瘦素和胰岛素对下丘脑的作用;;;;Leptin resistance;;;胰岛素抵抗，insulin resistance(IR);;动脉粥样硬化, artherosclerosis(AS);;;复习思考题