肠炎病毒ppt课件.pptVIP

HEPATITIS VIRUSES肝炎病毒;Hepatitis A virus，HAV甲型肝炎病毒;Biological Properties ;;Pathogenesis致病性;HAV的致病性;Asymptomatic infections are very common. As already noted, disease in children is generally milder than that in adults and is usually asymptomatic隐性感染多 No a chronic infection and carrier,not associated with hepatic cancer.无慢性病例和病毒携带者，不与肝癌有关 Complete recovery:99% 预后好 Fulminant hepatitis暴发性肝炎: 1~3 / 1000, 80% mortality rate死亡率 Pregnant women may develop more severe disease. 孕妇感染严重 ;Mechanisim of pathogenisis致病机理：;;immunity免疫性;Laboratory Diagnosis微生物学检查;Treatment and Prevention防治原则;hepatitis B virus, HBV乙型肝炎病毒;SHAPE AND STRUCTURE形态结构;Dane particle;HBV的小球形颗粒;HBV的管形颗粒;Genome of HBV;Antigen of HBV抗原组成;hepatitis B e antigen e抗原HBeAg the best correlate to the presence of infectious virus. 感染性病毒存在的最有效证据（复制及具传染性的标志） anti-HBe indicates low infectivity in a carrier 抗HBe说明病毒感染性较低（是预后良好的征象） ;culture培养 resistance抵抗力 strong resistance to cool,dry, ultraviolet, alcohol inactivate: 100℃ 10min;Pathogenesis and Immunity source of infection传染源 patients or carriers 急性、慢性患者或无症状HBsAg携带者 route of transmission传播途径 sexual routes parenteral肠胃外的 routes injection of the virus into the blood stream contaminated blood and blood components by transfusion, needle sharing, acupuncture针灸, ear piercing, or tattooing perinatal围产期 routes contact with the mother’s blood at birth and in mother’ milk ;Pathogenesis of HBV致病性;Clinical Findings ;Acute infection ;Fulminant hepatitis暴发型肝炎 ;Chronic infection ;Primary hepatocellular carcinoma （PHC）原发性肝细胞癌 ;;Laboratory Diagnosis乙肝“两对半”及临床意义 ;; HBV抗原抗体系统检测临床意义;Treatment and Prevention;hepatitis C virus,HCV丙型肝炎病毒;Biological properties生物学性状;Pathogenesis and Immunity致病性与免疫性;Pathogenesis;Laboratory diagnosis;hepatitis D virus，HDV丁型肝炎病毒;Pathogenesis;Laboratory diagnosis;hepatitis E virus，HEV戊型肝炎病毒;spread by the fecal-oral route为粪－口途径传播 symptoms and course of HEV disease are similar to those of HAV disease 症状病程类似HAV