（牙龈病）ppt课件.pptVIP

Li Deyi;Main Points: The virulence factors of periodontal pathogens The interaction of pathogens with the host in periodontal diseases;Contents of this lesson: Text book: P27-32 P150-152 Supplementary reading material;一. Preface;;Classification System for Periodontal Diseases (1999);7;8;9;10;Bacteria;二. Microbiologic Aspects of the Microbe - Host Interaction;Periodontal Pathogens Convincing Data Exist Significant Evidence (证据充分) (中等证据) Actinobacillus actinomycetemcomitans Campylobacter rectus (伴放线放线杆菌　Aa) (直肠弯曲菌) Porphyromonas gingivalis Eubacterium nodatum (牙龈卟啉单胞菌　Pg) (缠结优杆菌) Bacteroides forsythus Fusobacteruim nucleatum (福塞似杆菌　Bf) (具核梭杆菌　Fn) Prevotella intermedia (中间普氏菌　Pi) Peptostreptocoscus micros (微小消化链球菌　Pm) Streptococci intermedius (中间链球菌群) Treponema denticola (牙密螺旋体　Td);1. Colonization and Survival in the Periodontal Regionattachment(附着) or adhesion, multiplication(繁殖) and growth;Selected Bacterial Adhesins;16;2. Bacterial Invasion(入侵) of Host Tissue;18;19;3. Bacterial Evasion (逃避) of Host Defense Degradation of specific antibody Pg (IgA, IgG) Inhibition of IL-8 (production by EC) Pg Kill Leukocytes (produce leukotoxin) Aa (neutrophils, monocytes, lymphocytes) ;;4. Microbial Mechanisms of Host Tissue Damage;Bacterial Enzymes Capable of Degrading Host Tissues;Metabolic Products Ammonia Volatile sulfur compounds Fatty acids Peptides Indole;5. Calculus – Calcified Dental Plaque;26;27;三. Immunologic Aspects of the Microbe-Host Interaction; Complement (C3a,C5a) Neutrophil Mast cell;1. Neutrophils (嗜中性白细胞) Transendothelial migration (迁移) Chemotaxis (趋化) Opsonization (调理素) Phagocytosis (吞噬) Intraphagolysosomal (吞噬溶酶体) killing;2. Proteinases Matrix metalloproteinases, MMPs (基质金属蛋白酶) Degrade extracellular matrix molecules Collagen Gelatin Elastin ;3. Cytokines (细胞因子) Interleukin-1 (IL-1) IL-1α IL