对子宫肉瘤的治疗方式的更新ppt课件.pptVIP

Update on treatment modalities of uterine sarcomas;ENDOMETRIAL STROMAL SARCOMA ENDOMETRIAL CARCINOSARCOMA UTERINE LEIOMYOSARCOMA;New classification;Effective hormonal agents in recurrent setting;Role of BSO in ESS: Recurrence rates;Adjuvant progestins?Chu et al., Gynecol Oncol 2003:90:170-6;Retrospective study in ESS (n= 31)submitted;Retrospective study in ESS (n= 31)submitted;Indolent growth and hormone sensitivity: proposal for treatment;ENDOMETRIAL STROMAL SARCOMA ENDOMETRIAL CARCINOSARCOMA UTERINE LEIOMYOSARCOMA;Adjuvant chemotherapy Omura et al., J Clin Oncol 1985;3:1240-5 ;Benefit for multimodality adjuvant treatmentof endometrial carcinosarcoma;EORTC 55874: RT vs observation;Overview on spread pattern in different subtypes of endometrial cancer as reported in literatureAmant et al. Gynecol Oncol 2005;98:274-80;Improved survival in surgical stage I UPSC treated with adjuvant platinum based chemotherapyKelly et al., Gynecol Oncol 2005;98:353-359(Huh et al., Dietrich et al.);Adjuvant chemotherapy for surgical stage I CS in Leuven;Randall, M. E. et al. J Clin Oncol; 24:36-44 2006;Treatment of apparent early stage endometrial carcinosarcoma;Single agent chemotherapy in carcinosarcoma;Combination chemotherapy in carcinosarcoma;Randomised trial!Homesley et al., J Clin Oncol 2007;25:526-31;Single agent or combination chemotherapy in carcinosarcoma?;Trastuzumab in endometrial carcinosarcoma?;ENDOMETRIAL STROMAL SARCOMA ENDOMETRIAL CARCINOSARCOMA UTERINE LEIOMYOSARCOMA;Leiomyosarcoma: spread pattern;Single agent activity in leiomyosarcoma;Combination chemotherapy in leiomyosarcoma;C-kit as a target for anti-tyrosine-kinase in LMS?;Hormonal agents?;ET-743/ecteinascidin/Yondelis;Yondelis in Leuven: 2 US PD, 1/3 LMS responded ;ENDOMETRIAL STROMAL SARCOMA Hysterectomy only (no BSO) Adjuvant progestins? Repeat surgery ENDOMETRIAL CARCINOSARCOMA Adequate surgical staging Adjuvant platin based chemotherapy Paclitaxel-carboplatin UTERINE LEIOMYOSARCOMA Hyste